Our primary research interest is the research and development of novel small-molecules for the diagnosis and treatment of cancer and other types of cancer targeting epigenetics pathways with some medicinal chemistry strategies. Besides, we also focuses on the biology/biochemistry/pharmacology study for assay development, in-depth molecular signaling networks and evaluations of the biological activity of new compounds in relevant biochemical assays and laboratory models of human cancer, including patient derived xenograft model. We also employs comprehensive molecular mechanism studies for the progression of gastric cancer, discovery of extracellular vesicles-based biomarkers for precision medicine, drug target identification.
- 表观遗传及蛋白质翻译后修饰调控蛋白靶向小分子抑制剂的发现：LSD1、BRD4、USP7、NEDDylation相关抑制剂的发现。
- 表观遗传及蛋白质翻译后修饰相关蛋白生物学功能研究：（1）LSD1对胃癌EMT的调控作用；（2）USP7对胃癌细胞增殖和免疫微环境的调节作用；（3）胃癌及食管癌发生发展中关键蛋白对铁死亡的调节机制等。
- 外泌体相关研究：（1）外泌体蛋白及miRNA对靶细胞的生物功能调节作用；（2）外泌体中关键因子在消化道肿瘤个体化给药中的作用。