2024

  1. Maa Mamun, Yi-Chao Zheng, Ning Wang, Bo Wang, Yu Zhang, Jing-Ru Pang, Dan-Dan Shen, Hong-Min Liu*, Ya Gao*. Decoding CLU (Clusterin): Conquering cancer treatment resistance and immunological barriers. International Immunopharmacology, 2024, 137, 112355.
  2. Jiang-Wan Wu, Ying Liu, Xing-Jie Dai, Hong-Min Liu, Yi-Chao Zheng*, Hui-Min Liu*. CD155 as an emerging target in tumor immunotherapy. International Immunopharmacology, 2024, 131, 111896.
  3. Xing-Jie Dai, Shi-Kun Ji, Meng-Jie Fu, Gao-Zhi Liu, Hui-Min Liu, Shao-Peng Wang, Liang Shen, Ning Wang, Piet Herdewijn, Yi-Chao Zheng, Sai-Qi Wang*, Xiao-Bing Chen*. Degraders in epigenetic therapy: PROTACs and beyond. Theranostics, 2024, 14(4):1464-1499.
  4. Hui-Min Liu, Ying Zhou, He-Xiang Chen, Jiang-Wan Wu, Shi-Kun Ji, Liang Shen, Shao-Peng Wang, Hong-Min Liu, Ying Liu*, Xing-Jie Dai*, Yi-Chao Zheng*. LSD1 in drug discovery: From biological function to clinical application. Medicinal Research Reviews, 2024, 44(2):833-866.
  5. Binglei Zhang, Jianxiang Shi, Xiaojing Shi, Xiaolu Xu, Le Gao, Song Li, Mengmeng Liu, Mengya Gao, Shuiling Jin, Jian Zhou, Dandan Fan, Fang Wang, Zhenyu Ji, Zhilei Bian, Yongping Song, Wenzhi Tian, Yichao Zheng*, Linping Xu*, Wei Li*. Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy. Drug Resistance Updates, 2024, 74, 101068.
  6. Xing-Jie Dai, Shi-Kun Ji, Meng-Jie Fu, Gao-Zhi Liu, Hui-Min Liu, Shao-Peng Wang, Liang Shen, Ning Wang, Piet Herdewijn, Yi-Chao Zheng, Sai-Qi Wang*, Xiao-Bing Chen*. Degraders in epigenetic therapy: PROTACs and beyond. Theranostics, 2024, 14(4), 1464-1499.
  7. Ning-Jie Guo, Bo Wang, Yu Zhang, Hui-Qin Kang, Hai-Qian Nie, Meng-Kai Feng, Xi-Ya Zhang, Li-Juan Zhao, Ning Wang, Hong-Min Liu, Yi-Chao Zheng*, Wen Li*, Ya Gao*. A comprehensive review: Protein homeostasis and an emerging therapeutic target. International Journal of Biological Macromolecules, 2024, 130309.
  8. Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin*, Ying Liu*, Yi-Chao Zheng*. Neddylation-dependent LSD1 destabilization inhibits the stemness and chemoresistance of gastric cancer. International Journal of Biological Macromolecules, 2024, 254(3), 126801.

2023

  1. Chunlong Zhao, Yu Zhang, Jin’ge Zhang, Shunda Li, Mengyang Liu, Yinping Geng, Fengling Liu, Qipeng Chai, Hongwei Meng, Mengzhe Li, Jintao Li, Yichao Zheng*, Yingjie Zhang*. Discovery of Novel Fedratinib-Based HDAC/JAK/BRD4 Triple Inhibitors with Remarkable Antitumor Activity against Triple Negative Breast Cancer. Journal of Medicinal Chemistry, 2023, 66, 20, 14150–14174.
  2. M.A.A. Mamun, Ying Liu, Yin-Ping Geng, Yi-Chao Zheng, Ya Gao, Jian-Gang Sun, Long-Fei Zhao, Li-Juan Zhao, Hong-Min Liu*. Discovery of neddylation E2s inhibitors with therapeutic activity. Oncogenesis, 2023, 12(1):45.
  3. M.A.A. Mamun, Shuan Liu, Lijie Zhao, Lijuan Zhao, Zhong-Rui Li, Dandan Shen, Yu Zheng, Yi-Chao Zheng*, Hong-Min Liu*. Micafungin: A promising inhibitor of UBE2M in cancer cell growth suppression. European Journal of Medicinal Chemistry, 2023, 260, 115732.
  4. Xing-Jie Dai, Ying Liu, Ning Wang, He-Xiang Chen, Jiang-Wan Wu, Xiao-Peng Xiong, Shi-Kun Ji, Ying Zhou, Liang Shen, Shao-Peng Wang, Hong-Min Liu, Hui-Min Liu*, Yi-Chao Zheng*. Novel acridine-based LSD1 inhibitors enhance immune response in gastric cancer. European Journal of Medicinal Chemistry, 2023, 259, 115684.
  5. M A A Mamun, Yu Zhang, Jin-Yuan Zhao, Dan-Dan Shen, Ting Guo, Yi-Chao Zheng, Li-Juan Zhao*, Hong-Min Liu*. LSD1: an emerging face in altering the tumor microenvironment and enhancing immune checkpoint therapy. Journal of Biomedical Science, 2023, 60.
  6. Xiao-Nan Zhang, Ya Gao, Xi-Ya Zhang, Ning-Jie Guo, Wen-Qing Hou, Shu-Wu Wang, Yi-Chao Zheng, Ning Wang, Hong-Min Liu, Bo Wang*. Detailed curriculum vitae of HER2-targeted therapy. Pharmacology & Therapeutics, 2023, 245, 108417.
  7. Hui-Min Liu, Xiao-Peng Xiong, Jiang-Wan Wu, He-Xiang Chen, Ying Zhou, Shi-Kun Ji, Xing-Jie Dai*, Yi-Chao Zheng*, Hong-Min Liu*. Discovery of acridine-based LSD1 inhibitors as immune activators targeting LSD1 in gastric cancer. European Journal of Medicinal Chemistry, 2023, 251, 115255.
  8. Yuanzai Zhu, Mengkai Feng, Bo Wang, Yichao Zheng, Dandan Jiang, Lijuan Zhao, M.A.A. Mamun, Huiqin Kang, Haiqian Nie, Xiya Zhang, Ningjie Guo, Shangshang Qin, Ning Wang, Hongmin Liu*, Ya Gao*. New insights into the non-enzymatic function of HDAC6. Biomedicine & Pharmacotherapy, 2023, 161, 114438.
  9. Xing-Jie Dai#, Li-Juan Zhao#, Longhua Yang#, Ting Guo, Lei-Peng Xue, Hong-Mei Ren, Zhi-Li Yin, Xiao-Peng Xiong, Ying Zhou, Shi-Kun Ji, Hui-Min Liu, Hongmin Liu*, Ying Liu*, Yi-Chao Zheng*. Phenothiazine-Based LSD1 Inhibitor Promotes T-Cell Killing Response of Gastric Cancer Cells. Journal of Medicinal Chemistry, 2023, 66(6):3896–3916.
  10. Xing-Jie Dai, Lei-Peng Xue, Shi-Kun Ji, Ying Zhou, Ya Gao, Yi-Chao Zheng, Hui-Min Liu*, Hong-Min Liu*. Triazole-fused pyrimidines in target-based anticancer drug discovery. European Journal of Medicinal Chemistry, 2023, 249, 115101.
  11. Yi-Chao Zheng, Hui-Qin Kang, Bo Wang, Yuan-Zai Zhu, M. A. A. Mamun, Long-Fei Zhao, Hai-Qian Nie, Ying Liu, Li-Juan Zhao, Xiao-Nan Zhang, Mei-Mei Gao, Dan-Dan Jiang, Hong-Min Liu*, Ya Gao*. Curriculum vitae of HDAC6 in solid tumors. International Journal of Biological Macromolecules, 2023, 230, 123219.

2022

  1. Dan-Dan Shen, Jing-Ru Pang, Ya-Ping Bi, Long-Fei Zhao, Yin-Rui Li, Li-Juan Zhao, Ning Wang, Ya Gao, Bo Wang, Hong-Min Liu*, Yi-Chao Zheng*. LSD1 deletion decreases exsomal PD-L1 and restores T cell response in gastric cancer. Molecular Cancer, 2022, 21: 75.
  2. Long-Fei Zhao, Jin-Ge Zhang, Feng-Yu Qi, Wei-Yan Hou, Yin-Rui Li, Dan-Dan Shen, Li-Juan Zhao, Lin Qi*, Hong-Min Liu*, Yi-Chao Zheng*. SDC: An Integrated Database for Sex Differences in Cancer. Computational and Structural Biotechnology Journal, 2022, 20, 1068-1076.
  3. Dandan Shen, Bo Wang, Ya Gao, Lijuan Zhao, Yaping Bi, Jinge Zhang, Huiqin Kang, Jingru Pang, Ying Liu, Luping Pang, Zhe-Sheng Chen, Yichao Zheng*, Hong-Min Liu*. Detailed resume of RNA m6A demethylases. Acta Pharmaceutica Sinica B, 2022, 12(5), 2193-2205.
  4. Long-Fei Zhao, Feng-Yu Qi, Jin-Ge Zhang, Jing-Ru Pang, Hong-Mei Ren, Dan-Dan Shen, Li-Juan Zhao, Lin Qi*, Hong-Min Liu*, Yi-Chao Zheng*. Identification of the upstream regulators of KDM5B in gastric cancer. Life Sciences, 2022, 298, 120458.
  5. Yi-Chao Zheng, Yue-Jiao Liu, Ya Gao, Bo Wang*, Hong-Min Liu*. An Update of Lysine Specific Demethylase 1 Inhibitor: A Patent Review (2016-2020). Recent Patents on Anti-Cancer Drug Discovery, 2022, 17(1): 9-25.
  6. Yazhen You, Yundong Fu, Mingjie Huang, Dandan Shen, Bing Zhao, Hongmin Liu, Yichao Zheng, Lihua Huang*. Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases. International Journal of Molecular Sciences, 2022, 23(10), 5815.

2021

  1. Li-Juan Zhao, Ying-Ying Li, Yu-Tong Zhang, Qi-Qi Fan, Hong-Mei Ren, Cheng Zhang, Adil Mardinoglu, Wen-Chao Chen, Jing-Ru Pang, Dan-Dan Shen, Jun-Wei Wang, Long- Fei Zhao, Jian-Ying Zhang, Zhen-Ya Wang, Yi-Chao Zheng*, and Hong-Min Liu*. Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness. Embo Reports, 2021, e50922.
  2. Yingjie Chang, Jinge Zhang, Shuangshuang Yang, Wanying Lu, Lina Ding, Yichao Zheng*, Wen Li*. Design, synthesis, biological evaluation, and molecular docking of 1,7-dibenzyl-substituted theophylline derivatives as novel BRD4-BD1-selective inhibitors. Medicinal Chemistry Research, 2021, https://doi.org/10.1007/s00044-021-02737-2.
  3. Yi-Chao Zheng, Yan-Jia Guo, Bo Wang, Chong Wang, M.A.A. Mamun, Ya Gao*, Hong-Min Liu*. Targeting neddylation E2s: a novel therapeutic strategy in cancer. Journal of Hematology & Oncology, 2021, 14:57.
  4. Xing-Jie Dai, Ying Liu, Lei-Peng Xue, Xiao-Peng Xiong, Ying Zhou, Yi-Chao Zheng*, and Hong-Min Liu*. Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1. Journal of Medicinal Chemistry, 2021, 64, 5, 2466–2488.
  5. Zhiru Wang, Wenting Kang, Ouwen Li, Fengyu Qi, Junwei Wang, Yinghua You, Pengxing He, Zhenhe Suo, Yichao Zheng*, Hongmin Liu*. Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing. Acta Pharmaceutica Sinica B, 2021, 11 (3), 694-707. AAAS Featured papers
  6. Xinhui Zhang#, Huiqin Kang#, Yuanyuan Tao, Yihan Li, Junru Zhao, Ya Gao*, Liying Ma*, Hongmin Liu*, Identification of novel 1,3-diaryl-1,2,4-triazole-capped histone deacetylase 6 inhibitors with potential anti-gastric cancer activity, European Journal of Medicinal Chemistry, 2021, 218: 0223-5234.
  7. Xin-Hui Zhang, Qian Guo, Heng-Ying Wang, Yi-Han Li, Mussa Yussuf Khamis, Li-Ying Ma, Bo Wang*, Hong-Min Liu*. Gramine-based structure optimization to enhance anti-gastric cancer activity. Bioorganic Chemistry, 2021, 107, 104549.
  8. Chrisanta Harakandi, Lauraine Nininahazwe, Haiwei Xu, Bingrui Liu, Chenghua He, Yi-Chao Zheng, HangZhang*. Recent advances on the intervention sites targeting USP7-MDM2-p53 in cancer therapy. Bioorganic Chemistry, 2021, 116, 105273.
  9. Shixiang Wang, Yi Xiong, Longfei Zhao, Kai Gu, Yin Li, Fei Zhao, Jianfeng Li, Mingjie Wang, Haitao Wang, Ziyu Tao, Tao Wu, Yichao Zheng, Xuejun Li*, Xue-Song Liu*. UCSCXenaShiny: an R/CRAN package for interactive analysis of UCSC Xena data. Bioinformatics, 2021, 38:2, 527-529.
  10. Hang Zhang, Mingliang Zhang, Yi-Chao Zheng, Jin-Ge Zhang, Haiwei Xu*. The design, synthesis and cellular imaging of a tumor-anchored, potent and cell-permeable BRD4-targeted fluorescent ligands. Bioorganic Chemistry, 2021, 114, 105120.
  11. Jin-Ling Huo, Lemin Jiao, Qi An, Xiuying Chen, Yuruo Qi, Bingfei Wei, Yichao Zheng, Xiaojing Shi, Erhe Gao, Hong-Min Liu, Dong Chen*, Cong Wang*, Wen Zhao*. Myofibroblast deficiency of LSD1 alleviates TAC-induced heart failure. Circulation Research, 2021, 129: 400–413.

2020

  1. Xing-Jie Dai, Ying Liu, Xiao-Peng Xiong, Lei-Peng Xue, Yi-Chao Zheng*, and Hongmin Liu*. Tranylcypromine based Lysine-Specific Demethylase 1 inhibitor: Summary and Prospective. Journal of Medicinal Chemistry, 2020, 63, 23, 14197–14215.
  2. Jiangang Sun, Dandan Shen, Yichao Zheng*, Hongmei Ren, Hongmin Liu, Xiaoping Chen, Yongshun Gao*. USP8 Inhibitor Suppresses HER-2 Positive Gastric Cancer Cell Proliferation and Metastasis via the PI3K/AKT Signaling Pathway. OncoTargets and Therapy, 2020, 13, 9941-9952.
  3. Jiangang Sun, Dandan Shen, Yongshun Gao*, Yichao Zheng*, Lijuan Zhao, Mamum Maa, Hongmin Liu, Xiaoping Chen. Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation. OncoTargets and Therapy, 2020, 13, 7973–7984.
  4. Jiangang Sun, Yichao Zheng, Maa Mamun, Xiaojing Li, Xiaoping Chen, Yongshun Gao. Research progress of PD-1/PD-L1 immunotherapy in gastrointestinal tumors. Biomedicine & Pharmacotherapy, 2020, 129, 110504.
  5. Yi-Chao Zheng, Si-Qi Feng. Epigenetic Modifications as Therapeutic Targets. Current Drug Targets, 2020, 21:11, 1046.
  6. Li-Juan Zhao, Qi-Qi Fan, Ying-Ying Li, Hong-Mei Ren, Ting Zhang, Shuan Liu, Mamun Maa, Yi-Chao Zheng*, Hong-MinLiu*. LSD1 deletion represses gastric cancer migration by upregulating a novel miR-142-5p target protein CD9. Pharmacological Research, 2020, 159, 104991.
  7. Juan Li, Qingli Wang, Yichao Zheng, Piao Zhou, Xia Xu, Xueqi Liu, Longfei Zhao, Hongmin Liu*. Development of a mass spectrometry-based pseudotargeted metabolomics strategy to analyze hormone-stimulated gastric cancer cells. Journal of Pharmaceutical and Biomedical Analysis. 2020, 180, 113041.
  8. Moges Dessale Asmamaw, Ying Liu, Yi-Chao Zheng, Xiao-Jing Shi*, Hong-Min Liu*. Skp2 in the ubiquitin‐proteasome system: A comprehensive review. Medicinal Research Reviews, 2020, https://doi.org/10.1002/med.21675.
  9. Liying Ma, Haojie Wang, Yinghua You, Chaoya Ma, Yuejiao Liu, Feifei Yang, Yichao Zheng*, Hongmin Liu*. Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors. Acta Pharmaceutica Sinica B, 2020, 10(6): 1658-1668.
  10. Bing Zhao#, Qianqian Liang#, Hongmei Ren#, Xinhui Zhang, Yang Wu, Kun Zhang, Li-Ying Ma*, Yi-Chao Zheng*, Hong-Min Liu*. Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B). European Journal of Medicinal Chemistry. 2020, 192, 112161.
  11. Zhong-Rui Li, Feng-Zhi Suo, Yan-Jia Guo, Hai-Fang Cheng, Sheng-Hui Niu, Dan-Dan Shen, Li-Juan Zhao, Zhen-Zhen Liu, Mamun MAA, Bin Yu*, Yi-Chao Zheng*, Hong-Min Liu*. Natural protoberberine alkaloids, identified as potent selective LSD1 inhibitors, induce AML cell differentiation. Bioorganic Chemistry, 2020, 97, 103648.
  12. Siqi Feng, Anqi Li, Yi-Chao Zheng*, Hong-Min Liu*. Role of Drug-Metabolizing Enzymes in Cancer and Cancer Therapy. Current Drug Metabolism, 2020, doi: 10.2174/1389200221666200103111053.
  13. Peng-xing He⁎, Zhi-lu Ma, Huan Han, Xu-yang Zhang, Sheng-hui Niu, Lin-na Du, Yi-chao Zheng⁎, Hong-min Liu⁎. Expression of programmed death ligand 1 (PD-L1) is associated with metastasis and differentiation in gastric cancer. Life Sciences, 2020, 242: 117247.
  14. Shuai Wang, Dandan Shen, Lijie Zhao, Xiaohan Yuan, Jialing Cheng, Bin Yu*, Yichao Zheng*, Hongmin Liu*. Discovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4 (BRD4) inhibitors. Chinese Chemical Letters, 2020, 31(2): 418-422.
  15. Xin-Hui Zhang1, Bo-Wang1, Yuan-Yuan Tao, Qin Ma, Hao-Jie Wang, Zhang-Xu He, Hui-Pan Wu, Yi-Han Li, Bing Zhao, Li-Ying Ma*, Hong-Min Liu*. Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents. European Journal of Medicinal Chemistry, 2020, 199, 112349.

2019

  1. Hong-Min Liu, Feng-Zhi Suo, Xiao-Bo Li, Ying-Hua You, Chun-Tao Lv, Chen-Xing Zheng, Guo-Chen Zhang, Yue-Jiao Liu, Wen-Ting Kang, Yi-Chao Zheng*, Hai-Wei Xu*. Discovery and synthesis of novel indole derivatives-containing 3-methylenedihydrofuran-2(3H)-one as irreversible LSD1 inhibitors. European Journal of Medicinal Chemistry, 2019, 175, 357-372.
  2. Zhiru Wang, Wenting Kang, Yinghua You, Jingru Pang, Hongmei Ren, Zhen-He Suo*, Hong-Min Liu* and Yi-Chao Zheng*. USP7: Novel Drug Target in Cancer Therapy. Frontiers in Pharmacology, 2019, 10: 427.
  3. Zhong-Rui Li, Ting Ma, Yan-Jia Guo, Bo Hu, Sheng-Hui Niu, Feng-Zhi Suo, Lin-Na Du, Ying-Hua You, Wen-Ting Kang, Shuan Liu, MAA Mamun, Qi-Meng Song, Jing-Ru Pang, Yi-Chao Zheng*, Hong-MinLiu*. Sanggenon O induced apoptosis of A549 cells is counterbalanced by protective autophagy. Bioorganic Chemistry, 2019, 87, 688-698.
  4. Shuai Wang, Lijie Zhao, Xiao-Jing Shi, Lina Ding, Linlin Yang, Zhi-Zheng Wang, Dandan Shen, Kai Tang, Xiao-Jing Li, MAA Mamun, Huiju Li, Bin Yu*, Yi-Chao Zheng*, Shaomeng Wang*, and Hong-Min Liu*. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. Journal of Medicinal Chemistry, 2019, 62, 5, 2772-2797.
  5. Zhonghua Li, Lina Ding, Zhongrui Li, Zhizheng Wang, Fengzhi Suo, Dandan Shen, Taoqian Zhao, Xudong Sun, Junwei Wang, Ying Liu, Liying Ma, Bing Zhao, Pengfei Geng, Bin Yu*, Yichao Zheng*, Hongmin Liu*. Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A). Acta Pharmaceutica Sinica B. 2019, 9(4): 794-808.
  6. Yi-Chao Zheng, Jiao Chang, Lin-Chen Wang, Hong-Mei Ren, Jing-Ru Pang, Hong-Min Liu*. Lysine demethylase 5B (KDM5B): A potential anti-cancer drug target. European Journal of Medicinal Chemistry. 2019, 161(1), 131-140.
  7. Zhong-Rui Li, Feng-Zhi Suo, Bo Hu, Yan-Jia Guo, Dong-Jun Fu, Bin Yu*, Yi-Chao Zheng*, Hong-Min Liu*. Identification of osimertinib (AZD9291) as a lysine specific demethylase 1 inhibitor. Bioorganic Chemistry. 2019, 84, 164-169.
  8. Dan-Dan Shen, Feng-Zhi Suo, Qi-Meng Song, Jiao Chang, Ting Zhang, Jing-Jing Hong, Yi-Chao Zheng*, Hong-Min Liu*. Development of formaldehyde dehydrogenase-coupled assay and antibody-based assays for ALKBH5 activity evaluation. Journal of Pharmaceutical and Biomedical Analysis. 2019, 162(5), 9-15.
  9. Li-Juan Zhao#, Ting Zhang#, Xue-Jian Feng, Jiao Chang, Feng-Zhi Suo, Jin-Lian Ma, Ying-Jun Liu, Ying Liu, Yi-Chao Zheng*, Hong-Min Liu*. USP28 contributes to the proliferation and metastasis of gastric cancer. Journal of Cellular Biochemistry. 2019, 12(5): 7657-7666.
  10. Qi-Sheng Ma, Yongfang Yao, Yi-Chao Zheng, Siqi Feng, Junbiao Chang*, Bin Yu*, Hong-Min Liu. Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors. European Journal of Medicinal Chemistry. 2019, 162(15): 555-567.
  11. Ya Gao, Jinshan Xie, Ruotian Tang, Kaiyin Yang, Yahan Zhang, Lixia Chen*, Hua Lia*, Identification of a pyrimidinetrione derivative as the potent DprE1 inhibitor by structure-based virtual ligand screening, Bioorganic Chemistry, 2019, 85: 168-178
  12. Jing-Quan Wang1, Bo Wang1, Zi-Ning Lei, Qiu-Xu Teng, Jonathan Y. Li, Wei Zhang, Ning Ji, Chao-Yun Cai, Li-Ying Ma, Hong-Min Liu*, Zhe-Sheng Chen*. Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance. European Journal of Pharmacology, 2019, 863, 172611.
  13. Tao-Qian Zhao1, Yuan-Di Zhao1, Xin-Yang Liu, Zhong-Hua Li, Bo Wang, Xin-Hui Zhang, Ya-Quan Cao, Li-Ying Ma*, Hong-Min Liu*. Novel 3-(2,6,9-trisubstituted-9H-purine)-8-chalcone derivatives as potent anti-gastric cancer agents: Design, synthesis and structural optimization. European Journal of Medicinal Chemistry, 2019, 161, 493-505.

2018

  1. Yingchao Duan, Wenping Qin, Fengzhi Suo, Xiaoyu Zhai, Yuanyuan Guan, Xiaojuan Wang, Yichao Zheng*, Hongmin Liu*. Design, synthesis and in vitro evaluation of stilbene derivatives as novel LSD1 inhibitors for AML therapy. Bioorganic & Medicinal Chemistry. 2018, 26, 6000-6014.
  2. Xudong Sun, Yichao Zheng, Chaoya Ma, Jing Yang, Qibing Gao, Ying Yan, Zhizheng Wang, Wen Li, Wen Zhao, Hongmin Liu, Lina Ding*. Identifying the Novel Inhibitors of Lysine specific demethylase 1 (LSD1) Combining Pharmacophore-Based and Structure-Based Virtual Screening. Journal of Biomolecular Structure and Dynamics. 2019, 37(16), 4200-4214.
  3. Jin-Lian Ma, Ting Zhang, Feng-Zhi Suo, Jiao Chang, Xiang-Bin Wan, Xue-Jian Feng, Yi-Chao Zheng*, Hong-Min Liu*. Lysine-specific demethylase 1 activation by vitamin B2 attenuates efficacy of apatinib for proliferation and migration of gastric cancer cell MGC-803. Journal of Cellular Biochemistry. 2018, 119(6), 4957-4966.
  4. Jing Wang#, Mengzhu Zheng#, Qiuxia Min#, Ya Gao*, Weiguang Sun*, The dual regulatory function of lienal peptide on immune system, International Immunopharmacology, 2018, 55: 245-53
  5. Bo Wang1, Li-Ying Ma1, Jing-Quan Wang1, Zi-Ning Lei, Pranav Gupta, Yuan-Di Zhao, Zhong-Hua Li, Ying Liu, Xin-Hui Zhang, Ya-Nan Li, Bing Zhao*, Zhe-Sheng Chen*, Hong-Min Liu*. Discovery of 5 cyano-6-phenylpyrimidin derivatives containing an acylurea moiety as orally bioavailable reversal agents against P glycoprotein-mediated mutidrug resistance. Journal of Medicinal Chemistry, 2018, 61, 5988-6001.
  6. Bo Wang1, Bing Zhao1, Zhe-Sheng Chen, Lu-Ping Pang, Yuan-Di Zhao, Qian Guo, Xin-Hui Zhang, Ying Liu, Guang-Yao Liu, Hao-Zhang, Xin-Yuan Zhang, Li-Ying Ma*, Hong-Min Liu*. Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance. European Journal of Medicinal Chemistry, 2018, 143, 1535-1542.
  7. Yun-Kai Shi1, Bo Wang1, Xiao-Li Shi, Yuan-Di Zhao, Bin Yu*, Hong-Min Liu*. Synthesis and biological evaluation of new steroidal pyridines as potential anti-prostate cancer agents. European Journal of Medicinal Chemistry, 2018, 145, 11-22.
  8. Yuan-Di Zhao, Bo Wang, Jin-Zhi Liu, Pei Sun, Hong-Min Liu*. An overview on the method of determining the activity of indoleamine 2,3-dioxygenase 1. Journal of Drug Targeting, 2018, 1-14.
  9. Tao-Qian Zhao1, Yuan-Di Zhao1, Xin-Yang Liu, Bo Wang, Zhong-Hua Li, Zhang-Xu He, Xin-Hui Zhang, Jian-Jia Liang, Li-Ying Ma*, Hong-Min Liu*. Discovery of 6-chloro-2-(propylthio)-8,9-dihydro-7H-purines containing a carboxamide moiety as potential selective anti-lung cancer agents. European Journal of Medicinal Chemistry, 2018, 151, 327-338.

2017

  1. Kai Sun, Jia-Di Peng, Feng-Zhi Suo, Ting Zhang, Yun-Dong Fu, Yi-Chao Zheng*, Hong-MinLiu*. Discovery of tranylcypromine analogs with an acylhydrazone substituent as LSD1 inactivators: Design, synthesis and their biological evaluation. Bioorganic & Medicinal Chemistry Letters. 2017, 27(22), 5036-5039.
  2. Ying-Chao Duan, Yong-Cheng Ma, Wen-Ping Qin, Li-Na Ding, Yi-Chao Zheng, Ying-Li Zhu, Xiao-YuZhai, Jing Yang, Chao-Ya Ma, Yuan-Yuan Guan. Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment. European Journal of Medicinal Chemistry. 2017, 140(10), 392-402.
  3. Bo Wang, Bing Zhao, Lu-Ping Pang, Yuan-Di Zhao, Qian Guo, Jun-Wei Wang, Yi-Chao Zheng, Xin-Hui Zhang, Ying Liu, Guang-Yao Liu, Wen-Ge Guo, Chao Wang, Zhong-Hua Li, Xue-Jing Mao, BinY, Li-Ying Ma, Hong-Min Liu*. LPE-1, an orally active pyrimidine derivative, inhibits growth and mobility of human esophageal cancers by targeting LSD1. Pharmacological Research. 2017, 122, 66-77.
  4. Xiao Han, Zhiru Wang, Qing Cheng, Xiangru Meng, Donghui Wei, Yichao Zheng*, Jie Ding*, Hongwei Hou*. Mitochondria-dependent benzothiadiazole-based molecule probe for quantitatively intracellular pH imaging. Dyes and Pigments. 2017, 145, 576–583.
  5. Yi-Chao Zheng, Jiao Chang, Ting Zhang , Feng-Zhi Suo , Xiao-Bing Chen, Ying Liu , Bing Zhao, Bin Yu, Hong-Min Liu*. An Overview on Screening Methods for Lysine Specific Demethylase 1 (LSD1) Inhibitors. Current Medicinal Chemistry. 2017, 24(23):2496-2504.
  6. Zhong-Hua Li, Xue-Qi Liu, Peng-Fei Geng, Feng-Zhi Suo, Jin-Lian Ma, Bin Yu , Tao-Qian Zhao, Zhao-Qing Zhou, Chen-Xi Huang, Yi-Chao Zheng*, and Hong-Min Liu*. Discovery of [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Novel LSD1 Inhibitors. ACS Medicinal Chemistry Letter. 2017, 8, 384-389.
  7. Ying-Chao Duan, Yuan-Yuan Guan, Xiao-Yu Zhai, Li-Na Ding, Wen-Ping Qin, Dan-Dan Shen, Xue-Qi Liu, Xu-Dong Sun, Yi-Chao Zheng*, Hong-Min Liu*. Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation. European Journal of Medicinal Chemistry. 2017, 126, 246-258.
  8. Shuai Wang, Li-Jie Zhao, Yi-Chao Zheng, Dan-Dan Shen, Er-Fei Miao, Xue-Peng Qiao, Li-Juan Zhao, Ying Liu, Ruilei Huang, Bin Yu, Hong-Min Liu. Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors. European Journal of Medicinal Chemistry. 2017, 125, 940-951.
  9. Ya Gao#, Lihan Zhu#, Jing Guo, Ting Yuan, Liqing Wang, Hua Li*, Lixia Chen*, Farnesyl phenolic enantiomers as natural MTH1 inhibitors from Ganoderma sinense, Oncotarget, 2017, 8(56): 95865-79
  10. Biao Hu1, Bo Wang1, Bing Zhao, Qian Guo, Zhong-Hua Li, Xin-Hui Zhang, Guang-Yao Liu, Ying Liu, Ying Tang, Fan Luo, Ya Du, Ya-Xin Chen, Li-Ying Ma * and Hong-Min Liu*. Thiosemicarbazone-based selective proliferation inactivators inhibit gastric cancer cell growth, invasion, and migration. MedChemComm, 2017, 8, 2173-2180.
  11. Zhong-Hua Li1, Ji Zhang1, Xue-Qi Liu, Peng-Fei Geng, Jin-Lian Ma, Bo Wang, Tao-Qian Zhao, Bing Zhao, Hao-Ming Wei, Chao Wang, Dong-Jun Fu, Bin Yu*, Hong-Min Liu*. Identification of thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents through the drug repurposing strategy. European Journal of Medicinal Chemistry, 2017, 135, 204-212.
  12. Zhong-Hua Li1, Xue-Qi Liu1, Peng-Fei Geng, Ji Zhang, Jin-Lian Ma, Bo Wang, Tao-Qian Zhao, Bing Zhao, Xin-Hui Zhang, Bin Yu*, Hong-Min Liu*. Design, synthesis and antiproliferative activity of thiazolo[5,4-d] pyrimidine derivatives through the atom replacement strategy. European Journal of Medicinal Chemistry, 2017, 138, 1034-1041.

2016

  1. Yi-Chao Zheng, Dan-Dan Shen, Meng Ren, Xue-Qi Liu, Zhi-Ru Wang, Ying Liu, Qian-Na Zhang, Li-Juan Zhao, Li-Jie Zhao, Jin-Lian Ma, Bin-Yu, Hong-Min Liu. Baicalin, a natural LSD1 inhibitor. Bioorganic Chemistry. 2016, 69, 129-131.
  2. Yi-Chao Zheng, Jin-Lian Ma, Ying Liu, Hong-Min Liu*.Writers and Erasers of Histone Lysine methylation with Clinical Applied Modulators Promising Target for Cancer Therapy. Current Pharmaceutical Design. 2016, 22, 1-5.
  3. Yi-Chao Zheng, Bin Yu, Zhe-Sheng Chen, Ying Liu and Hong-Min Liu*. TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy. Epigenomics. 2016, 8(5), 651-666.
  4. Yi-Chao Zheng, Bin Yu, Guo-Zhong Jiang, Xue-Jian Feng, Peng-Xing He, Xiao-Yang Chu, Wen Zhao, Hong-Min Liu*. Irreversible LSD1 inhibitors: Application of tranylcypromine and its derivates in cancer. Current Topics in Medicinal Chemistry. 2016, 16(19): 2179-2188.
  5. Yi-Chao Zheng, Long-Zhen Wang, Li-Jie Zhao, Li-Juan Zhao, Qian-Na Zhan, Jin-Lian Ma, Bin Zhang, Meng-Meng Wang, Zhi-Ru Wang, Jin-Feng Li, Ying Liu, Zhe-Sheng Chen, Dan-Dan Shen, Xue-Qi Liu, Meng Ren, Wen-Lei Lv, Wen Zhao, Ying-Chao Duan, Hong-Min Liu1*. 1,2,3-triazole–dithiocarbamate hybrids, a group of novel cell active SIRT1 inhibitors. Cellular Physiology and Biochemistry. 2016, 38(1):185-193.
  6. Wray R#, Iscla I#, Ya Gao, Hua Li, Junmei Wang*, Paul Blount*, Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore, Plos Biology, 2016, 14(6): e1002473

~2015

  1. Yi-Chao Zheng, Jinlian Ma, Zhiru Wang, Jinfeng Li, Bailing Jiang, Wenjuan Zhou, Xiaojing Shi, Xixin Wang, Wen Zhao and Hong-Min Liu*. A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors. Medicinal Research Reviews, 2015, 35, 1032-1071.
  2. Yi-Chao Zheng#, Ying-Chao Duan#, Jin-Lian Ma, Rui-Min Xu, Xiaolin Zi, Wen-Lei Lv, Meng-Meng Wang, Xian-Wei Ye, Shun Zhu, David Mobley, Yan-Yan Zhu, Jun-Wei Wang, Jin-Feng Li, Zhi-Ru Wang, Wen Zhao, Hong-Min Liu*. Triazole-dithiocarbamate based, selective LSD1 inactivators inhibit gastric cancer cell growth, invasion and migration, Journal of Medicinal Chemistry, 2013, 56, 8543-8560.
  3. Li-Ying Ma#, Yi-Chao Zheng#, Sai-Qi Wang#, Bo Wang, Zhi-Ru Wang, Lu-Ping Pang, Miao-Zhang, Jun-Wei Wang, Li-Na Ding, Juan Li, Cong Wang, Biao Hu, Ying Liu, Xiao-Dan Zhang, Jia-Jia Wang, Zhi-Jian Wang, Wen Zhao* and Hong-Ming Liu*. Design, synthesis and structure-activity relationship of novel LSD1 inhibitors based on pyrimidine-thiourea-hybrids as potent, orally active antitumor agents. Journal of Medicinal Chemistry, 2015, 58, 1705-1716.
  4. Bin Yu, Yi-Chao Zheng, Xiao-Jing Shi, Ping-Ping Qi and Hong-Min Liu*. Natural product-derived spirooxindole fragments serve as privileged substructures for discovery of new anticancer agents. Anti-Cancer Agents in Medicinal Chemistry, 2016;16(10):1315-24.
  5. Xian-Wei Ye#, Yi-Chao Zheng#, Ying-Chao Duan, Meng-Meng Wang, Bin Yu, Jing-Li Ren, Jin-Lian Ma, En Zhang, Hong-Min Liu*. Synthesis and biological evaluation of coumarin-1, 2, 3-triazole-dithiocarbamate hybrids as potent LSD1 inhibitors. MedChemComm. 2014, 5, 650-654.
  6. Yi-Chao Zheng, Wen-Lei Lv, Jin-Lian Ma, Ang Yang, Jin-Feng Li, Zhi-Ru Wang, Wen Zhao, Hong-Min Liu*. Effects of novel triazole-dithiocarbamate based LSD1 selective inhibitors on gastric cancer cell growth, invasion and migration in vitro. Acta Pharmacologica Sinica, 2013, 34, 137-138.
  7. Jin-Lian Ma, Yi-Chao Zheng, Wen Zhao, Wen-Lei Lv, Ang Yang, Zhi-Ru Wang, Jin-Feng Li, Hong-Min Liu*. Bio-activity of novel Histone Lysine specific demethylase1inhibitorin human gastric cancer cell line MGC-803. Acta Pharmacologica Sinica, 2013, 34, 11-11.
  8. Ying-Chao Duan, Yi-Chao Zheng, Xiao-Chen Li, Meng-Meng Wang, Xian-Wei Ye, Yuan-Yuan Guan, Gai-Zhi Liu, Jia-Xin Zheng, Hong-Min Liu*. Design, synthesis and antiproliferative activity studies of novel 1, 2, 3-triazole-dithiocarbamate-urea hybrids. European Journal of Medicinal Chemistry, 2013, 64, 99-110.
  9. Wen-Lei Lv, Yi-Chao Zheng, Rui-Min Xu, Jin-Lian Ma, Ke Yang, Wen Zhao, Hong-Min Liu. Adenoviral construction of histone lysine specific demethylase 1 gene. Acta Pharmacologica Sinica, 2013, 34, 154-154.
  10. Marlein Miranda Cona, Matthias Bauwens, Yichao Zheng, Walter Coudyzer, Junjie Li, Yuanbo Feng, Huaijun Wang, Feng Chen, Alfons Verbruggen, Raymond Oyen, Yicheng Ni*. Study on the microbial safety of an infusion set for contrast-enhanced imaging. Investigative Radiology, 2012, 47, 247-251.
  11. Lijie Wang, Jiajie Fan, Zetan Cao, Yichao Zheng, Zhiqiang Yao, Guosheng Shao,* and Junhua Hu*. Fabrication of Predominantly Mn4+-Doped TiO2 Nanoparticles under Equilibrium Conditions and Their Application as Visible-Light Photocatalyts. CHEMISTRY-An Asian Journal, 2014, 9, 1904 – 1912.
  12. Bin Yu, Ping-Ping Qi, Xiao-Jing Shi, Ruilei Huang, Hao Guo, Yi-Chao Zheng, De-Quan Yu, Hong-Min Liu*. Efficient synthesis of new antiproliferative steroidal hybrids using the molecular hybridization approach. European Journal of Medicinal Chemistry, 2016, 12(117): 241-255.
  13. Wen Zhao, Wenjuan Zhou, Xiaojing Shi, Yichao Zheng, Huimin Wang, Xuepeng Geng, Shuang Zhang, Jingjing Wang, Hongmin Liu*. Prokaryotic expression, purification and activity evaluation of an antioxidant protein: peroxiredoxin II. Cardiology, 2014, 129, 56-57.
  14. Bin Yu, Xiao-Nan Sun, Xiao-Jing Shi, Ping-Ping Qi, Yi-Chao Zheng, De-Quan Yu*, Hong-Min Liu*. Efficient synthesis of novel antiproliferative steroidal spirooxindoles via the [3+2] cycloaddition reactions of azomethine ylides. Steroids, 2015, 102, 90-100.
  15. Li-Ying Ma, Bo Wang, Lu-Ping Pang, Miao Zhang, Sai-Qi Wang, Yi-Chao Zheng, Kun-Peng Shao, Deng-Qi Xue, Hong-Min Liu*. Design and synthesis of novel 1,2,3-triazole–pyrimidine–urea hybrids as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 1124-1128.
  16. Lanxia Zhao, Jing Liu, Longlong Zhang, Ya Gao, Zhiqing Zhang, Yuxia Luan*, Self-assembly properties, aggregation behavior and prospective application for sustained drug delivery of a drug-participating catanionic system, International Journal of Pharmaceutics, 2013, 452(1-2): 108–15
  17. Longlong Zhang, Jing Liu, Tingting Tian, Ya Gao, Xiaoqing Ji, Zhonghao Li, and Yuxia luan*, Pharmaceutically Active Ionic Liquid Self-Assembled Vesicles for the Application as an Efficient Drug Delivery System, Chemphyschem communication, 2013, 14(15): 3454-7