我们的主要研究方向聚焦于肿瘤等重大疾病的诊断与治疗相关新型小分子药物研发，重点围绕表观遗传学调控通路，系统引入药物化学与理性设计策略，并深入开展化学生物学研究：一方面，利用多样化的化学工具分子精准解析关键生物学过程与分子机制；另一方面，反向挖掘生物学调控规律，推动化学生物学新方法与新技术体系的创新发展。在此过程中，我们重点布局蛋白靶向降解（targeted protein degradation, TPD）相关的新策略与新方法，探索基于小分子、双功能分子及可编程化学工具的靶向降解体系，实现对复杂生物体系的精准、可控化学干预。在此基础上，我们结合生物学、生物化学与药理学研究，构建和优化功能检测体系（assay development），系统解析分子信号网络及其调控机制，并全面评估新化合物在多种生化实验和人类肿瘤相关模型中的生物学活性。此外，我们围绕胃癌与食管癌发生发展过程中的关键分子事件开展深入机制研究，致力于细胞外囊泡相关生物标志物的发现与转化应用，推进精准医学，并同步开展药物作用靶点的鉴定与功能验证，为创新抗肿瘤治疗策略的建立提供坚实的理论与实验基础。我们的主要研究方向包括：
（1）致病蛋白在传统酶活之外的功能特性，探索新的调控规律与干预思路。
（2）细胞外环境中影响疾病进程的关键因素，发展相应的精准调控策略。
（3）利用核酸和多肽等可设计分子构建可编程的调控与干预工具。
（4）围绕转录、翻译和蛋白稳态等关键环节，开发调控细胞内病理过程的创新方法。
Our research focuses on developing novel small-molecule therapeutics for the diagnosis and treatment of cancers and other major diseases, with a particular emphasis on epigenetic regulatory pathways. By integrating medicinal chemistry, rational design, and advanced chemical biology approaches, we aim to dissect key biological processes with molecular precision, uncover regulatory principles that drive method innovation, and establish new strategies within the targeted protein degradation (TPD) field. We explore degradation platforms based on small molecules, bifunctional chimeras, and programmable chemical tools to achieve precise and controllable modulation of complex biological systems. Building on this foundation, we incorporate biological, biochemical, and pharmacological approaches to construct and optimize functional assay systems, elucidate signaling networks and their regulatory mechanisms, and comprehensively evaluate the biological activities of new compounds across diverse biochemical and cancer models. In parallel, we investigate critical molecular events in gastric and esophageal cancer progression, including the discovery and translational application of extracellular vesicle–based biomarkers, and conduct systematic target identification and functional validation to support the development of innovative anticancer strategies and advance precision medicine.
(1) Investigate the non-enzymatic functional properties of disease-associated proteins and identify new principles and strategies for their regulation.
(2) Examine key extracellular factors that influence disease progression and develop precise methods for their modulation.
(3) Design programmable molecular tools based on nucleic acids and peptides to enable versatile biological regulation.
(4) Establish innovative strategies to modulate pathological cellular processes by targeting critical steps in transcription, translation, and protein homeostasis.